Clue contest No 40

Overreaction perhaps beginning to get really ridiculous (7)

(G(ET) + REALLY)*; def is "overreaction perhaps" (the body "overreacting" to something)

Altered state of sensitivity in smaller gym largely amazing (7)

Def=altered state of sensitivity, in smALLER GYmn, also anag (amazing) of "largely"

Missing you, lurgy mixed with ale leads to heightened state of sensitivity (7)

LURGY "missing you" (-U) = LRGY, "mixed with" ALE; Def: heightened state of sensitivity

Really good juggling to get reaction (7)

Def = reaction (REALLY + G )* juggling

Colleague has a certain amount of work aversion (7)

ALLY (colleague) containing ERG (a unit of work). Def: aversion

Angry response when picture house drops its premiere (7)

(G>>)ALLERY. Down clue

Odd reaction from a student touching cloth when caught short (7)

A+L +/touching [C]LERGY

Reaction from drug used in every topless sex party (7)

E (drug) in ALL (every) + [o]RGY (topless sex party)

Large lady's clothing provoked unwanted reaction (7)

Anag. ('provoked') of LARGE + LY ('lady's clothing') = Def. ('unwanted reaction')

Unfortunately No 2 for Plymouth Argyle gets bad reaction (7)

Anag (unfortunately) of l (no 2 for Plymouth) and Argyle

Inability to tolerate really grand design (7)

ALLERGY (inability to tolerate) = anagram (design) of REALLY + G (grand)

Cloudy cycling back after all, possibly provoking asthma (7)

ALL+ERGY (GREY reversed with the Y cycled) = dbe (possibly provoking asthma)

Negative reaction from back benches after leader moves to the right (7)

Drag and drop G (leader) in GALLERY (back benches)

Ministers' leader slain after gangster's overly sensitive reaction (7)

AL (gangster - Al Capone) + LERGY (clergy - ministers minus first letter) Def: overly sensitive reaction

Between beginning of April and end of May, pupils start experiencing raised groin hypersensitivity (7)

A[pril..ma]Y around LL (pupils) E R G (start Experiencing Raised Groin); hypersensitivity = def. For some unfortunate individuals, could be seen as an &lit.?

Discordant symphony’s ending “left Elgar in hives”? (7)

(Y [symphonY's ending]) + L [left] + ELGAR)* [anag:"discordant"]. "Hives" as DbE (shown by ?)

Controversial gallery generates adverse reaction (7)

(GALLERY)* / anagram indicator = "controversial"

Reaction everyone consequently contracted with eye burning outside (7)

ALL + ERG[o] + [e]Y[e] — all (everyone) + ergo contracted (minus last letter) + eye burning outside letters

Qualification required before course can be delivered? (7)

Cryptic def

E.g. rally: appalling overreaction (7)

*eg rally (appalling)

Reaction to bugs from partner’s bedding, so backside needs to be scratched (7)

Def: reaction to bugs. ALLY is containing ERG(O)

Largely mistreated health issue (7)

Def: health issue. Anagram (mistreated) of LARGELY

Teetotaller gynecologist exhibits particular sensitivity (7)

hidden

Character at front of audience shows delayed reaction (7)

The G in GALLERY appears late; def = reaction

Really good exercises for asthma? (7)

(REALLY + G('good'))*, anagrind 'exercises', link 'for', DBE 'asthma?'

This could make a lentil eater groggy on vacation (7)

&lit: This / A + outer letters (on vacation) of LentiL EateR GroggY

Nice to go on vacation of gaudy distaste (7)

ALLER ('to go' in Nice, France) + GY (GaudY on vacation) def = distaste (eg. "I have an allergy/distaste for xyz")

Partner taking on Republican in, for example, reactionary state? (7)

Def: reactionary state?; WP is a matryoshka construction: ALL{E{R}G}Y (R in EG; which is all in ALLY)